Decapeptide-12 (Topical)
Decapeptide-12 200mg
Decapeptide-12 is an oligopeptide with well-known anti-tyrosinase activity. It is under active investigation for its ability to help improve both skin tone and skin texture. Tyrosinase is a copper-containing enzyme found widely in plant and animal tissues. It catalyzes the production of melanin and other pigments. By interfering with tyrosinase, decapeptide-12 is able to lighten skin tone in animal models.
Sequence (Three-Letter Code): Tyr-Arg-Ser-Aar-Lysd-Tyr-Ser-Ser-Trp-Tyr
Molecular formula: C65H90N18O17
Molecular weight: 1311.46 g/mol
Research Application:
Tyrosinase is an enzyme essential to the production of melanin and other pigments. A deficiency of tyrosinase results in type I oculocutaneous albinism while any mutation that causes tyrosinase to be overactive will lead to hyperpigmentation of the skin secondary to melanin production [1]. Both the medical and cosmetics industries are interested in tyrosinase inhibitors, like decapeptide-12, as both therapeutics and to help better clarify how the enzyme cascade of pigment production works.
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The food industry has also investigated decapeptide-12 as a potential preservative and flavor enhancer. Tyrosinase catalyzes the oxidation of phenolic compounds found in fruits and vegetables (it is what turns potatoes black after they are cut) to quinones. This conversion gives food an unpleasant taste and color. It also makes it harder for certain proteins to be digested and thus decreases the nutritional value of food.
Tyrosinase has a number of unique roles in the insect world. It can affect wound healing, parasite encapsulation, and the formation of an insect’s hard exosekleton. Inhibitors of tyrosinase, like decapeptide-12, have been studied as potential insecticides.
What Is Decapeptide-12?
Decapeptide-12 is a small oligopeptide made of just twelve amino acids (Tyr-Arg-Ser-Aar-Lysd-Tyr-Ser-Ser-Trp-Tyr). It is primarily known for its ability to inhibit activity of the tyrosinase enzyme responsible for producing melanin.
What Does Decapeptide-12 Do?
Decapeptide-12 reversibly binds to tyrosinase, an enzyme found in a number of different pigment-producing cells. It prevents tyrosinase from catalyzing the oxidation of phenols, the first step in melanin production. In mammals, tyrosinase is found only in melanosomes, special compartments within pigment-producing cells. Tyrosinase is not preserved across species and, in fact, can differ drastically in structure even among closely-related species. In humans, differences in the efficiency of tyrosinase determine skin color and are the result of slight modifications in the TYR gene found on chromosome 11 [2].
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